Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury

✍ Scribed by Dr. Moritaka Goto; Sunao Kawano; Harumasa Yoshihara; Yoshiyuki Takei; Taizo Hijioka; Hiroyuki Fukui; Takashi Matsunaga; Masahide Oshita; Toru Kashiwagi; Hideyuki Fusamoto; Takenobu Kamada; Nobuhiro Sato

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 746 KB
• Volume: 15
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840150313

✦ Synopsis

The purpose of this study was to determine whether hepatic tissue oxygenation after ischemia-reperfusion procedures is an indicator for later liver injury. Partial ischemia in the liver was induced by ligating the left pedicles. Rats were divided into two groups according to duration of ischemia: group A (30-min ischemia) and group B (60-min ischemia). Indices of blood oxygenation and blood volume in regional hepatic tissue, serum ALT levels and histological appearance of livers were evaluated. Twenty-four hours after ischemia and reflow, all rats in group A were alive, whereas only 67% survived in group B. Blood-oxygenation index and blood-volume index in group A rats rebounded quickly after reperfusion. In group B, blood-oxygenation index and blood-volume index remained significantly lower than in group A after reperfusion. Serum ALT levels at 60 and 120 rnin after reperfusion in group B were significantly higher than those in group A. Bloodoxygenation index measured at 5 and 60 min of reperfusion showed significant correlation with serum ALT levels at 120 min of reperfusion. When the percentage