Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats

✍ Scribed by K. Rathinam; S. P. Srivastava; Prahlad K. Seth

• Book ID: 102289316
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 281 KB
• Volume: 10
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550100107

✦ Synopsis

Adult male rats reciving tris(2-ethyl hexy1)trimellitate (TOTM) intraperitoneally for seven days exhibited no significant changes in the activities of hepatic aminopyrine-N-demethylase, aryl hydrocarbon hydroxylase or glutathione-S-transferase, or in the glutathione contents. However, except for the glutathione level, the di(2ethyl hexy1)phthalate (DEHP)-treated group showed significant increases in the activities of these enzymes. Changes in the body weight and the absolute and relative liver weights were also observed among the DHEPtreated group.

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