Hepatic parenchymal changes after ethanol injection in rabbits: Correlation of conventional and dynamic MR imaging with pathologic findings
✍ Scribed by Takeshi Fujita; Katsuyoshi Ito; Takashi Choji; Kazumitsu Honjo; Takeshi Arita; Naofumi Matsunaga
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 723 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
The purpose of this study is to clarify the changes of peripheral normal liver parenchyma before and after ethanol injection. with respect to MR appearances and pathologic flndings and, in so doing, to clinically evaluate the therapeutic effectiveness of percutaneous ethanol injection (PEI) therapy. The normal liver in 12 rabbits was injected with ethanol. We performed conventional and dynamic M R imaging and prepared the histopathologic specimens 1 week (group 1). 2 weeks (group 2), and 1 month (group 3) after ethanol injection. On conventional M R images, coagulative necrosis in the normal liver was demonstrated as M area of low signal intensity on T1-weighted images and high signal intensity on T2-weighted images in all groups. On dynamic M R images, contrast enhancement in the coagulative necrosis was not seen in groups 1 and 2; however, gradual and concentric enhancement was seen in the direction of the central necrotic portion from early-to-delayed phase image in group 3. Although signal intensity of the coagulative necrotic area in the normal liver after ethanol injection may mimic that of untreated or viable hepatocellular carcinoma (HCC) when clinically encountered on conventional M R images. coagulative necrosis of the normal liver parenchyma w i l l be discriminated from viable HCC by using dynamic M R imaging.