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Hepatic mitochondrial glutathione: transport and role in disease and toxicity

✍ Scribed by Jose C. Fernandez-Checa; Neil Kaplowitz

Book ID
113923482
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
279 KB
Volume
204
Category
Article
ISSN
0041-008X

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Long-term ethanol feeding has been shown to selectively reduce hepatic mitochondrial glutathione content by impairing mitochondrial uptake of this thiol. In this study, we assessed the role of this defect in evolution of alcoholic liver disease by examining the mitochondrial glutathione pool and lip