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Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat

✍ Scribed by Jenny Odum; Terry C. Orton

Book ID
115776948
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
481 KB
Volume
32
Category
Article
ISSN
0006-2952

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Glucuronidation of carboxylic acids, primarily catalyzed by hepatic UDPglucuronosyltransferases, is an important phase II metabolic pathway functioning in detoxification. Acyl glucuronides of 2-aryl propionates, however, can form covalently bound protein adducts, which may generate hypersensitive re