Hepatic intra-arterial infusion of vincristine

✍ Scribed by Don V. Jackson; Frederick Richards; Charles L. Spurr; Tony R. Long; Duff A. Rardin; David A. Albertson; J. Michael Sterchi

• Book ID: 104686968
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 270 KB
• Volume: 13
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00257127

✦ Synopsis

Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial.