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Hepatic injury during ketoconazole therapy in patients with onychomycosis: A controlled cohort study

✍ Scribed by R. Chien; L. Yang; P. Lin; Y. Liaw

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 665 KB
Volume: 25
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.510250119

No coin nor oath required. For personal study only.

✦ Synopsis

duced hepatitis is often diagnosed by exclusion, so that the To evaluate the incidence, severity, and course of ketopossibility of hepatitis C virus (HCV) infection has not been conazole-associated hepatic injury, 211 patients with excluded in most reports, because serological markers for onychomycosis were randomized by a ratio of 2:1 to re-HCV were not available before 1989. 27 Therefore, we have ceive either ketoconazole (137 patients) or griseofulvin conducted this controlled, cohort study to examine the inci-(74 patients). All of them were seronegative for hepatitis dence, severity, and clinical course of ketoconazole-induced B surface antigen (HBsAg) and anti-hepatitis C virus hepatic injury. (HCV) and had no biochemical abnormality before therapy. The two groups were comparable in age, sex, and PATIENTS AND METHODS pretherapy liver biochemical tests. Liver biochemical

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