Hepatic fibrosis produced in guinea pigs by chronic ethanol administration and immunization with acetaldehyde adducts
✍ Scribed by Hirokazu Yokoyama; Shigeyuki Nagata; Susumu Moriya; Shinzo Kato; Takashi Ito; Kiyotaka Kamegaya; Hiromasa Ishii
- Book ID
- 102852385
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 624 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
The role of autoimmunity in alcohol-induced liver disease has been a subject of long-standing discussions.' Recently, acetaldehyde, the first metabolite of ethanol, has been demonstrated to contribute the formation of acetaldehyde adducts and the generation of ethanol-induced neo-epitopes in uiuo. Several studies have shown that exposure to ethanol leads to the formation of acetaldehyde adducts in the livers of experimental in cultured hepatocyte~,~ and in both the liver and the blood of a l c o h o l i ~s . ~~~
The proteinacetaldehyde adducts act as neoantigens capable of