Hepatic enzyme induction postpones the onset of sodium retention in experimental cirrhosis in rats induced by bile duct excision

Phenobarbital influences the development

Phenobarbital influences the development of sodium retention in liver disease induced by bile duct ligation in the rat

✍ Georg Wensing; Robert A. Branch 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

The onset of sodium retention in phenobarbitalharbon tetrachloride-induced cirrhosis in rats is preceded by a linear decrease in hepatic function as assessed by the aminopyrine rate constant of elimination. Sodium retention occurs when liver function decreases below a critical aminopyrine rate const