Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: Lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors

Affinities and densities of high-affinit

Affinities and densities of high-affinity [3H]muscimol (GABA-A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

✍ Roger F. Butterworth; Joël Lavoie; Jean-François Giguère; Gilles Pomier-Layrargu 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

The integrity of GABA-A receptors and of central benzodiazepine receptors was evaluated in membrane preparations from prefrontal cortex and caudate nuclei obtained at autopsy from nine cirrhotic patients who died in hepatic coma and an equal number of agematched control subjects. Histopathological s