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Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: A clinical and pharmacologic evaluation

✍ Scribed by L.B.J. van Iersel; M.R. Verlaan; A.L. Vahrmeijer; E.L. van Persijn van Meerten; F.G.J. Tijl; R.W. Sparidans; H. Gelderblom; P.J.K. Kuppen; R.A.E.M. Tollenaar; C.J.H. van de Velde

Book ID: 116442954
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 308 KB
Volume: 33
Category: Article
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2007.02.022

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Isolated hepatic perfusion with high-dos

Isolated hepatic perfusion with high-dose melphalan for the treatment of colorectal metastasis confined to the liver

✍ J. Rothbarth; M. E. J. Pijl; A. L. Vahrmeijer; H. H. Hartgrink; F. G. J. Tijl; P 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 1 views

## Abstract ## Background Isolated hepatic perfusion (IHP) involves complete vascular isolation of the liver to allow treatment with doses that would be toxic if delivered systemically. A phase II study of IHP in patients with colorectal metastases confined to the liver was performed. ## Methods