Hepatic arterial infusion chemotherapy with 5-fluorouracil-based regimens in the management of liver metastases of colorectal carcinoma
β Scribed by Hiroshi Seki; Motomasa Kimura; Norihiko Yoshimura; Toshirou Ozaki; Kunio Sakai
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 491 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1341-9625
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## BACKGROUND. Pharmacokinetic modulating chemotherapy (PMC) is a new therapeutic concept in combination with continuous 5-fluorouracil (5-FU) infusion and UFT. UFT enhanced plasma 5-FU concentration and antitumor effects during 5-FU infusion. The authors report on their experiences with arterial
Twenty-seven patients with measurable liver metastases from colorectal carcinoma were entered on a protocol of intermittent hepaticartery infusion (HAI) of 5-fluorouracil(5-FU) followed by consolidation with hepatic irradiation. Five partial responses were observed in 23 evaluable patients. Median d