Hepatic angiosarcoma in a child: Successful therapy with surgery and adjuvant chemotherapy

✍ Scribed by Gunawardena, Sriya W.; Trautwein, Lynn M.; Finegold, Milton J.; Ogden, Angela K.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 217 KB
• Volume: 28
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199702)28:2<139::aid-mpo9>3.0.co;2-l

✦ Synopsis

We report a 3-year and 11-month-old Caucasian female, who initially presented with an unresectable hepatic angiosarcoma. After three courses of chemotherapy with adriamycin/cisplatin, the tumor decreased in size considerably, allowing complete surgical resection. She also received postoperative chemotherapy with alternating cycles of ifosfamide/etoposide, cisplatinum/adriamycin, and vincristine/actinomycin D/cyclophosphamide for 18 months. She remains disease-free for greater than 44 months from the initial diagnosis. Our experience suggests that total excision of the tumor, together with an aggressive chemotherapy regimen, can improve the disease-free survival for children with this highly malignant vascular tumor of the liver.