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Hepatic and intestinal handling of metabolites during feeding in rats

✍ Scribed by W. Langhans


Book ID
118354655
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
585 KB
Volume
49
Category
Article
ISSN
0031-9384

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Hepatic and intestinal first-pass effect
✍ Soo K. Bae; Jin W. Kim; Young H. Kim; Yoon G. Kim; Sang G. Kim; Myung G. Lee πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 82 KB πŸ‘ 2 views

It was reported that the mean value of the extent of absolute oral bioavailability (F) of oltipraz at a dose of 20 mg/kg was 41.2% and only 2.68% of the oral dose was unabsorbed from the gastrointestinal tract in rats. Hence, the low F in rats could be due to considerable first-pass (gastric, intest