Hepatic and gastrointestinal first-pass effects of vitexin-4″- O -glucoside in rats
✍ Scribed by Chen, Yinghui; Zhang, Wenjie; Li, Di; Ai, Junjun; Meng, Yihan; Ying, Xixiang; Kang, Tingguo
- Book ID
- 124160012
- Publisher
- Pharmaceutical Press
- Year
- 2013
- Tongue
- English
- Weight
- 361 KB
- Volume
- 65
- Category
- Article
- ISSN
- 2042-7158
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Pharmacokinetic parameters of metformin were evaluated after intravenous and oral administration (50, 100, and 200 mg/kg) in rats. The hepatic, gastric, and intestinal first-pass effects were also measured after intravenous, intraportal, intragastric, and intraduodenal administration (100 mg/kg) in
It was reported that the mean value of the extent of absolute oral bioavailability (F) of oltipraz at a dose of 20 mg/kg was 41.2% and only 2.68% of the oral dose was unabsorbed from the gastrointestinal tract in rats. Hence, the low F in rats could be due to considerable first-pass (gastric, intest