Heparinized saline to aid aspiration of blood clots during laparoscopy
✍ Scribed by C. C. Nduka; A. Darzi
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 242 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
✦ Synopsis
The second issue is the subgroup analysis. This is a highly controversial manoeuvre that should only ever be used to generate hypotheses'. Given the limited size of the overall study, which arguably was too small to detect clinically important differences in the entire population, it is almost pointless to look for modest but clinically important differences in subgroups. I therefore disagree strongly with Dr Albers' assertion that the subgroup results support the in situ technique. Both the small sample size for the subgroup analyses and, importantly, the limitations of subgroup analyses per se, mean that the data neither support nor refute the use of in situ bypass. The data are simply uninformative and, had the authors followed the statistical guidelines of the Journal and presented results accompanied by 95 per cent confidence intervals, this would have been readily apparent.