Heparin Inhibits the Motility and Proliferation of Human Myometrial and Leiomyoma Smooth Muscle Cells
β Scribed by Holly R. Mason; Romana A. Nowak; Cynthia C. Morton; John J. Castellot Jr.
- Book ID
- 117022157
- Publisher
- American Society for Investigative Pathology
- Year
- 2003
- Tongue
- English
- Weight
- 819 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0002-9440
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## Abstract Heparin is a well established growth inhibitor of arterial smooth muscle cells (SMCs) both in animal models and in vitro. Even though the cellular mechanisms involved in the antiβproliferative properties of heparin are being resolved, the structural requirements for the biological effec
The binding, internalization, and metabolism of 13H]-heparin by human umbilical vein endothelial cells (HUVEC) and human umbilical arterial smooth muscle cells (HUASMC) have been characterized using 5ize-exclusion HPLC. Incubation of HUVEC with ['HI-heparin demonstrated selective binding of high-mol