Heparin elimination following continuous infusion during intra-aortic balloon counterpulsation
✍ Scribed by Jacob, Andrew S. ;Steingart, Richard H. ;Schweger, Marc J.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 237 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0098-6569
No coin nor oath required. For personal study only.
✦ Synopsis
The decline of the activated partial thromboplastin time (APTT) following discontinuation of heparin infusion was measured in six intra-aortic balloon pump (IABP) patients. The heparin infusion requirement was determined for eight other IABP patients during stable therapeutic anticoagulation. Following discontinuation of infusion, APTT declined with a relatively constant half-life (tY2 of 2.4 f 0.08 hr, suggesting elimination by first-order kinetics. In comparison, the tVz following single bolus doses has been shown to be markedly dose dependent, increasing from 30 min at low doses to 2 hr at very high doses. The heparin requirement for IABP patients was found to be 16 f 2.5 Ulkglhr, similar to that reported for other clinical situations. The t% of the APTT following discontinuation of heparin infusion can be used to time invasive procedures that would best be done with normal hemostasis.