Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta
β Scribed by Wallace L. Mc Keehan; Pamela S. Adams
- Book ID
- 112799767
- Publisher
- Society for In Vitro Biology
- Year
- 1988
- Tongue
- English
- Weight
- 293 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1475-2689
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## Abstract Insulinβlike growth factor binding proteinβ3 (IGFBPβ3) has been proposed to mediate the growth inhibitory effects of transforming growth factor (TGF)βΞ² in breast and prostate cancer cells. Both TGFβΞ² and exogenous IGFBPβ3 inhibit DNA synthesis in Mv1 mink lung epithelial cells (CCL64).
Transforming growth factor-beta (TGF-P) exerts several effects on cultured airway epithelial cells including inhibition of proliferation and stimulation of fibronectin gene expression. ADP-ribosylation is one potential regulatory mechanism of gene expression by TGF-P. We tested this possibility by e