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Heparan sulphate proteoglycan and wound healing in skin

✍ Scribed by McGrath, John A.; Eady, Robin A. J.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 27 KB
Volume: 183
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199711)183:3<251::aid-path969>3.0.co;2-h

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✦ Synopsis

Normal wound healing in skin embraces several reparative processes, many of which directly involve components of the extracellular matrix and the cutaneous basement membrane zone. Proteoglycans are a group of extracellular matrix macromolecules that have both structural and regulatory properties. In wound healing, certain proteoglycans fulfill a mechanical function of absorbing water and preventing tissue compression. However, proteoglycans may also have other roles in wound healing including a direct influence on inflammation, cell attachment and migration, and growth factor binding. Furthermore, proteoglycans may help to determine other aspects of the long-term quality of wound healing in skin through regulation of basement membrane permeability, epidermal hyperproliferation, and dermal fibrosis.

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