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Heparan Sulfate Mediates the Proliferation and Differentiation of Rat Mesenchymal Stem Cells

โœ Scribed by Dombrowski, Christian; Song, Shu Jun; Chuan, Peiying; Lim, Xinhong; Susanto, Evelyn; Sawyer, Amber A.; Woodruff, Maria A.; Hutmacher, Dietmar W.; Nurcombe, Victor; Cool, Simon M.

Book ID
120081761
Publisher
Mary Ann Liebert
Year
2009
Tongue
English
Weight
419 KB
Volume
18
Category
Article
ISSN
1547-3287

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## Abstract Human mesenchymal stem cells (MSCs) reside under hypoxic conditions in vivo, between 4% and 7% oxygen. Differentiation of MSCs under hypoxic conditions results in inhibited osteogenesis, while chondrogenesis is unaffected. The reasons for these results may be associated with the inheren