Hemostatic Efficacy of Biological Self-Assembling Peptide Nanofibers in a Rat Kidney Model

✍ Scribed by Hong Song; Lanlan Zhang; Xiaojun Zhao

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 635 KB
• Volume: 10
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200900129

✦ Synopsis

Abstract

We evaluated the hemostatic efficacy of a biological self‐assembling peptide RADA16‐I in a rat kidney injury model. Adult male rats were randomized into five groups: sham operation (no renal excision), no hemostatic agent (control), commercially available gelatin sponge (Gelfoam), 1% RADA16‐I, and 2% RADA16‐I. After left partial nephrectomy, the anesthetized animal was anticoagulated using 300 IU · kg^−1^ heparin, and the topical hemostatic agent was applied to the injury. Blood loss and mean arterial pressure (MAP) were recorded. As was the case for Gelfoam, 2% RADA16‐I produced marked hemostasis versus controls (p < 0.01). Blood loss with 1% and 2% RADA16‐I was significantly less than controls. The decline in MAP during surgery was less with 2% versus 1% RADA16‐I. RADA16‐I also resulted in less histological tissue responses than Gelfoam. These data suggest that RADA16‐I can stop hemorrhage, with only minimal tissue responses, in experimental renal injury.

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