Content: Part I: Introduction to the field of hemostasis and thrombosis. Coagulation enzymology --
Cell biology, protein processing, and cell signaling --
Cellular and molecular immunology --
Biostatistics and epidemiology: the basic science of clinical research --
Part II: Basic hemostasis and thrombosis. Coagulation & fibrinolysis --
Overview of basic coagulation and fibrinolysis --
The blood coagulation factors and inhibitors: complementary DNAs, genes and expression --
Genetics of coagulation proteins --
Tissue factor and the initiation and regulation (TFPI) of coagulation --
Factors V and VIII --
Structure and function of von Willebrand factor --
Structure and function of vitamin K-dependent coagulant and anticoagulant proteins --
Factor XI --
The Factor XII-driven plasma contact system --
Fibrinogen structure and function --
Factor XIII --
Antithrombin and the serpin family --
Protein C and S and thrombomodulin system --
Plasminogen activation and regulation of fibrinolysis --
Inhibitors of fibrinolysis --
Platelet biology --
Overview of platelet structure and function --
Platelet production: cellular and molecular regulation --
Megakaryocyte structure and platelet biogenesis --
Thrombopoietin --
Major platelet glycoproteins: GPIb-IX-V --
Major platelet glycoproteins: GPIIb/IIIa --
Platelet glycoprotein polymorphisms and relationship to function and immunogenicity --
The basis for platelet adhesion --
Shear effects on platelets and the vessel wall in the pathogenesis of atherothrombosis --
Platelets and collagen --
Integrin [alpha]iib [beta]3 and platelet aggregation --
Molecular basis for platelet secretion --
Platelet signal transduction --
Platelet prostaglandin metabolism --
The role of platelets in blood coagulation --
Blood-borne microparticles --
Overview of vascular biology --
Development of the vasculature, angiogenesis, lymphangiogenesis --
Rheology and vessel wall stress --
Nitric oxide --
Blood vessel wall in health and disease --
Endothelial cell function --
Role of endothelium in hemostasis --
Coagulation-independent signaling of the extrinsic coagulation pathway --
Heparin and vascular proteoglycans --
Endothelial cell-blood cell interactions --
Leukocyte function and contribution to disease --
Laboratory markers of endothelial cell activation and dysfunction --
Part III: Disorders of coagulation, platelets, and vessel wall. Bleeding disorders coagulation & fibrinolysis --
Overview of inherited hemorrhagic disorders --
Differential diagnosis of the bleeding patient --
Clinical manifestations and therapy of inherited and acquired hemophilia --
von Willebrand Disease: diagnosis, classification, and treatment --
Rare inherited coagulation disorders other than hemophilia --
Afibrogenemias and dysfibrogenemias --
Familial multiple coagulation factor deficiencies --
Clinical disorders of fibrinolysis --
Acquired disorders of coagulation: the immune coagulopathies --
Laboratory markers of coagulation and fibrinolysis --
Acquired & inherited platelet disorders --
Overview of acquired and inherited clinical platelet disorders --
Differential diagnosis of thrombocytopenia --
Immune thrombocytopenic purpura and posttransfusion purpura --
Drug-induced thrombocytopenia --
Inherited thrombocytopenias --
Acquired nonimmune thrombocytopenia --
Hereditary disorders of platelet function --
Acquired disorders of platelet function --
Laboratory markers of platelet activation --
Primary disorders of blood vessels --
Overview of primary disorders of blood vessels --
Disorders of connective tissue and extracellulara matrix --
Hereditary hemorrhagic telangiectasia --
Arteriovenous malformations and hemangiomas and cerebral cavernous malformations --
Aneurysms (large and small arteries) --
Intracranial hemorrhage --
Retinopathy --
Therapy of bleeding disorders --
Overview to therapy of bleeding disorders --
Management of acute hemorrhage --
Therapy with antifibrinolytic agents --
Transfusion medicine --
New approaches for the therapy of bleeding disorders, including gene therapy. Part IV: Thrombotic disorders. venous thrombotic disorders. Thrombophilia genetics --
Epidemiology and risk factors of venous thromboembolism --
Clinical manifestations and diagnosis of venous thromboembolism --
Venous thrombosis in unusual sites --
Sequelae of venous thromboembolic disease: postthrombotic syndrome and chronic thromboembolic pulmonary hypertension --
Prevention of venous thromboembolic disease --
Treatment of venous thromboembolic disease --
Arterial thrombotic disorders --
Overview of arterial thrombotic disorders --
Pathophysiology of atherosclerosis --
Acute coronary syndromes: manifestations and management --
Pathophysiology of thromboembolic stroke --
Prevention of thromboembolic stroke in patients with atrial fibrillation, valvular heart disease, cardiomyopathy --
Acute stroke: general management, anticoagulant, and thrombolytic therapy --
Medical and surgical treatment of peripheral arterial disease --
Unusual sites of arterial occlusion --
Pathogenesis and treatment of biomaterial-associated thrombosis --
Complex thrombotic disorders --
Overview of microvascular and complex thrombotic disorders --
Consumptive thrombohemorrhagic disorders --
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome-microangiopathies --
Vasculitides --
Antiphospholipid antibodies and the antiphospholipid syndrome --
Thrombohemorrhagic complications of myeloproliferative disorders --
Thrombotic and hemorrhagic complications associted with stem cell transplantation --
Therapeutic agents --
Overview of therapeutic agents used in thrombotic disorders --
Pharmacology and mode of action of heparin and glycosaminoglycans --
Vitamin K antagonists: biochemistry, pharmacology and management --
Hemorrhagic complications of anticoagulation --
Heparin-induced thrombocytopenia --
Coumarin-induced skin necrosis and venous limb gangrene --
New antithrombotic drugs --
Antiplatelet therapy --
Thrombolytic therapy --
Anticoagulant and procoagulant proteins in the animal kingdom --
Mechanical devices and embolectomy --
Part V: Hemostatic and thrombotic disorders associated with systemic conditions. overview of special clinical groups --
VTE during pregnancy and with hormonal contraceptives --
Gestational vascular complications --
Maternal hemostatic disorders and obstetric hemorrhage --
Developmental hemostasis --
Bleeding in neonates and children --
Venous and arterial thromboembolism in children --
Thrombotic complications of sickle cell disease --
Thrombohemorrhagic complications of sepsis --
Hemorrhagic fevers: epidemiology, pathophysiology, and clinical features --
Cancer-related thrombosis --
Hemostatic abnormalities in liver disease --
Hemostatic abnormalities in renal disease --
Multitrauma derangements in hemostasis and thrombosis --
Blood management in the cardiovascular surgery patient --
Thrombo-hemorrhagic events in the elderly.