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Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

✍ Scribed by Sun, Jiying; Hoshino, Hideto; Takaku, Kazuaki; Nakajima, Osamu; Muto, Akihiko; Suzuki, Hiroshi; Tashiro, Satoshi; Takahashi, Satoru; Shibahara, Shigeki; Alam, Jawed

Book ID: 111749823
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 304 KB
Volume: 21
Category: Article
ISSN: 0261-4189
DOI: 10.1093/emboj/cdf516

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The gene expression of heme oxygenase-1 (HO-1) was studied in mammalian cell lines exposed to hyperoxia. Northern blot analysis demonstrated that hyperoxic exposure increased the HO-1 mRNA levels in various types of cells, including human hepatoma (HepG2) cells. This increase was time-and dose-depen