Hemopoietic environment necessary for an early stage in differentiation of antibody-forming cells: Effect of cortisol

✍ Scribed by Michael Bennett

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 782 KB
• Volume: 76
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040760210

✦ Synopsis

Abstract

Treatment of adult mice with cortisol decreased the number and frequency of bone marrow precursors of anti‐sheep erythrocyte hemolytic plaque‐forming cells (P‐PFC) and marrow “lymphocytes.” However, the more primitive progenitors of P‐PFC in marrow were not affected. Treatment of prospective recipients of marrow grafts with cortisol impaired the generation of P‐PFC by transplanted primitive progenitor cells. Differentiation with proliferation of P‐PFC into mature PFC was less dramatically affected by cortisol. P‐PFC were not apparently suppressed directly, since the fall‐off of P‐PFC did not occur during the first day after administration of cortisol. Thus, cortisol impairs the generation of P‐PFC by altering a hemopoietic inductive environment necessary for this step in differentiation of immunocompetent cells.