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Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-Butoxyethanol: I. Sensitivity in rats and resistance in normal humans

✍ Scribed by Mark M. Udden; Cynthia S. Patton

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
537 KB
Volume
14
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

The effects of butoxyacetic acid (BAA), a metabolite of the important solvent 2‐butoxyethanol, on rat and human red blood cells (RBCs) were investigated. Rat RBCs demonstrated decreased deformability as assessed by a sensitive polycarbonate sieve filtration technique and an increased mean cellular volume after incubation with 0.2 and 2.0 mM BAA for 1–4 h. Evaluation of erythrocyte morphology showed that rat RBCs exposed to BAA became spherocytic and lysed to form erythrocyte membrane ghosts. Hemolysis of rat erythrocytes was rapid in 2.0 mM BAA. Changes in the deformability of rat erythrocytes appear to precede hemolysis. Treated rat erythrocytes also demonstrated a tendency to agglutinate and to release hemoglobin, which formed visible precipitates. None of the adverse effects seen in the RBCs of rats were observed in human blood similarly incubated with 2.0 mM BAA.

📜 SIMILAR VOLUMES

Hemolysis and deformability of erythrocy
Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-Butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility
✍ Mark M. Udden 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 498 KB

## Abstract 2‐Butoxyethanol causes hemolysis in rodents but not in humans. 2‐Butoxyethanol‐induced hemolysis is primarily due to the effect of its metabolite 2‐butoxyacetic acid (BAA). 2‐Butoxyacetic acid did not cause hemolytic effects when incubated with blood from a limited number of normal indi