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Hemoglobin Switching in Sheep: Only the γ Gene is in the Active Conformation in Fetal Liver but all the β and γ Genes are in the Active Conformation in Bone Marrow

✍ Scribed by Neal S. Young, Edward J. Benz, Judith A. Kantor, Peter Kretschmer and Arthur W. Nienhuis

Book ID
123655423
Publisher
National Academy of Sciences
Year
1978
Tongue
English
Weight
940 KB
Volume
75
Category
Article
ISSN
0027-8424

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## Abstract PKCα was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the γ/γ + β