Hemoglobin New York in Chinese subjects in Taiwan

✍ Scribed by R. Q. Blackwell; C.-S. Liu; C.-L. Wang

• Book ID: 101459071
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 441 KB
• Volume: 34
• Category: Article
• ISSN: 0002-9483
• DOI: 10.1002/ajpa.1330340304

✦ Synopsis

Abstract

Hemoglobin K Kaohsiung has been found, during our population survey in Taiwan, in nine unrelated Chinese subjects with provincial origins from several parts of Mainland China and Taiwan. It also was seen in four relatives of the nine subjects. Present chemical structure studies indicate that it has the same structural anomaly as that previously reported in a variant found in members of a Cantonese Chinese family in New York. That variant, called Hemoglobin New York, has the structural change, β113 Valine→Glutamic acid. Preliminary evaluation suggests that this hemoglobin is one of the most common variants in Chinese population groups although it frequently may be undetected by the usual electrophoretic screening procedures. All of the subjects detected thus far were heterozygotes with nearly equal amounts of Hemoglobin A~o~ and K Kaohsiung. Hemoglobin K Kaohsiung exhibits slightly reduced heat stability compared with that of Hemoglobin A~o~; however, its presence in the heterozygote apparently causes no more than mild anemia.