Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

A programmed cell death pathway in the m

A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases

✍ Ch'ng, J-H; Kotturi, S R; Chong, A G-L; Lear, M J; Tan, K S-W 📂 Article 📅 2010 🏛 Nature Publishing Group 🌐 English ⚖ 963 KB

Several recent discoveries of the hallmark features of programmed cell death (PCD) in __Plasmodium falciparum__ have presented the possibility of revealing novel targets for antimalarial therapy. Using a combination of cell-based assays, flow cytometry and fluorescence microscopy, we detected featur