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Hemoglobin CHarlem: A sickling variant containing amino acid substitutions in two residues of the β-polypeptide chain

✍ Scribed by Robert M. Bookchin; Ronald L. Nagel; Helen M. Ranney; Alan S. Jacobs


Book ID
118849746
Publisher
Elsevier Science
Year
1966
Tongue
English
Weight
299 KB
Volume
23
Category
Article
ISSN
0006-291X

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Two new human hemoglobin variants caused
✍ H. Wajcman; Y. Blouquit; C. Vasseur; A. Querrec; M. Laniece; C. Melevendi; A. Ra 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 399 KB

With rare exceptions, the more than 600 human hemoglobin variants described are caused by a single point mutation. Other abnormal features, such as unequal crossing-over, frameshift mutagenesis or double mutations in the same polypeptide chain, have seldom been encountered. We report two new variant