Hemoglobin binding to Aβ and HBG2 SNP association suggest a role in Alzheimer's disease
✍ Scribed by Rodney T. Perry; Debra A. Gearhart; Howard W. Wiener; Lindy E. Harrell; James C. Barton; Abdullah Kutlar; Ferdane Kutlar; Ozan Ozcan; Rodney C.P. Go; William D. Hill
- Book ID
- 116781037
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 361 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0197-4580
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## Abstract Aggregated amyloid β‐peptide (Aβ) is the primary constituent of the extracellular plaques and perivascular amyloid deposits associated with Alzheimer's disease (AD). Deposition of the cerebral amyloid plaques is thought to be central to the disease progression. One such molecule that ha
Elevated levels of zinc 2+ and copper 2+ are found chelated to the amyloid-beta-peptide (Ah) in isolated senile plaque cores of Alzheimer's disease (AD) patients. However, the precise residues involved in Zn 2+ ligation are yet to be established. We have used 1 H NMR and CD to probe the binding of Z