โ Scribed by Thomas Ming Swi Chang (auth.), Hae Won Kim, A. Gerson Greenburg (eds.)
No coin nor oath required. For personal study only.
Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells....Pages 3-26
From the Atmosphere to the Mitochondrion: The Oxygen Cascade....Pages 27-53
Biochemistry of Hemoglobin....Pages 55-73
The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity....Pages 75-93
Front Matter....Pages 95-95
Pathophysiology of Hemorrhagic Shock and Resuscitation....Pages 97-116
Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage....Pages 117-126
Pre-Hospital Fluid Resuscitation in Civilian and Military Populations....Pages 127-138
Front Matter....Pages 139-139
NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics....Pages 141-147
Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials....Pages 149-156
Front Matter....Pages 157-157
HBOCs from Chemical Modification of Hb....Pages 159-183
Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids....Pages 185-234
Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure....Pages 235-247
Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock....Pages 249-272
Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application....Pages 273-282
Zero-Link Hemoglobin (OxyVita ยฎ ): Impact of Molecular Design Characteristics on Pre-clinical Studies....Pages 283-297
Polynitroxylated Pegylated Hemoglobin (PNPH): A Nanomedicine for Critical Care and Transfusion....Pages 299-313
ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications....Pages 315-337
Albumin-Heme Oxygen Carriers....Pages 339-348
Recombinant Human HbโSOD Fusion Proteins....Pages 349-358
InโVitro Production of Functional RBCs from Hematopoietic Stem Cells....Pages 359-366
Front Matter....Pages 367-367
Liposome-Encapsulated Hemoglobin: Potential Clinical Applications....Pages 369-383
Biocompatibility of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, on Blood Cells and Plasma Proteins In Vitro and In Vivo....Pages 385-397
Polymerized Human Placenta Hemoglobin: Organ Protective Effects and Alternative Clinical Uses....Pages 399-410
Low Volume Resuscitation with HBOCs in Hemorrhagic Shock....Pages 411-433
Ischemic Rescue with Hemoglobin-Based Oxygen Carriers....Pages 435-453
Front Matter....Pages 455-455
Pre-clinical Evaluation of Hemoglobin Based Oxygen Carriers: Animal Models and Biomarkers....Pages 457-474
The Hemoglobin-Based Oxygen Carrier, HBOC-201, as a Resuscitation Fluid for Traumatic Hemorrhagic Shock: The Naval Medical Research Center Experience....Pages 475-499
Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs....Pages 501-524
Front Matter....Pages 525-525
Key Adverse Events in Recent HBOC Phase III Clinical Trials and Their Causal Relationship to Test HBOCโs....Pages 527-542
Some Critical Comments on the Major HBOC Clinical Trials....Pages 543-562
Compassionate Use Cases Treated with Hemoglobin-Based Oxygen Carriers....Pages 563-584
Front Matter....Pages 585-585
Acellular Hemoglobin-Based Oxygen Carrier Mediated Blood Pressure Elevation and Vasoconstriction: A Review of Proposed Mechanisms and Contributing Factors....Pages 587-620
HBOCs and Cardiac Integrity....Pages 621-646
Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation....Pages 647-664
Redox Activity of Cell-Free Hemoglobin: Implications for Vascular Oxidative Stress and Endothelial Dysfunction....Pages 665-682
HBOC Interferences with Routine Clinical Laboratory Tests....Pages 683-692
Vasoconstriction, Hypertension and Oxidative Toxicity are Regulated by Polymerized Hemoglobin Size....Pages 693-711
Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies....Pages 713-733
Front Matter....Pages 735-735
International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation FluidsโA White Paper....Pages 737-746
Biomaterials; Molecular Medicine; Medicinal Chemistry; Hematology
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