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Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes

✍ Scribed by Michael Glei; Stefanie Klenow; Julia Sauer; Uta Wegewitz; Konrad Richter; Beatrice L. Pool-Zobel


Book ID
113808771
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
155 KB
Volume
594
Category
Article
ISSN
0027-5107

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The human colonic carcinoma cell line HT-29cl.19A responds to the protein kinase C activator PDB (4-beta-phorbol 12,13-dibutyrate), as it does to forskolin (an activator of adenylyl cyclase), with a secretory response when the cells are grown on filters and studied at 36 degrees C. Previously, we sh