## Abstract Among postโtranslational modifications of proteins, nonโenzymatic glycation is one of the less frequently studied by experts in proteomics. However, the relevance of protein glycation has been widely shown up in several pathological conditions. In fact, nonโenzymatic glycation has been
Hemoglobin, a model protein for studying non-enzymatic glycation
โ Scribed by Hiroshi Ueno; Yasuo Bai; Edward J. Yatco; Nobuhiro Mori; Hiroyuki Kagamiyama; James M. Manning
- Book ID
- 112212666
- Publisher
- AlphaMed Press
- Year
- 1994
- Tongue
- English
- Weight
- 860 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1066-5099
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Mass spectrometry has been applied successfully to the study of non-enzymatic protein glycation, which is a topic of wide interest in the diabetes field. Low- and high-resolution mass spectra, GC/MS, and collisional activation spectroscopy allow the structural identification and quantitative evaluat
## Abstract Recent studies on nonโenzymatic protein glycation are reviewed, and results are critically discussed. Advanced glycation end products (AGE) levels in the body reflect a balance between their formation and catabolism. AGE proteolysis leads to the formation of lowโmolecularโweight AGE (AG