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Hemocompatibility of high strength oxide ceramic materials: An in vitro study

✍ Scribed by Horst Fischer; Maria Luk; Bernward Oedekoven; Rainer Telle; Khosrow Mottaghy

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
129 KB
Volume
81A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

High strength oxide ceramic materials like alumina and zirconia are frequently used for artificial joints because of their biocompatibility and high wear resistance. Their suitability as materials for implants and biomedical devices with direct blood contact, such as cardiovascular implants or components for blood pumps and dialyzers, has not been confirmed to date. The objective of this study was to investigate whether oxide ceramics show sufficient hemocompatibility. Dense specimens were made out of alumina, zirconia, titanium oxide, and aluminum titanate. Polyvinylchloride and silicone were additionally tested as reference materials. Interactions of human blood with the surfaces were studied by investigating partial thromboplastin time (PTT), thrombin antithrombin III complex (TAT), free plasma hemoglobin concentration, complete blood count, complement factor 5a, and protein adsorption. The results from the PTT and TAT tests clearly indicated higher blood activation by the ceramic materials when compared to the two polymer materials. However, alumina and zirconia showed lower C5a concentrations and less protein adsorption than the reference materials. Our results revealed that oxide ceramic materials alone cannot be used for implants in direct blood contact without modification of the ceramic surface, for example, by made‐to‐measure inert nanocoatings. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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