Hemmung der Bernsteinsäure-Cytochrom-c-Reduktase und deren Reaktivierung durch isoprenartige Verbindungen

✍ Scribed by F. Weber; O. Wiss

• Publisher: John Wiley and Sons
• Year: 1959
• Tongue: German
• Weight: 360 KB
• Volume: 42
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19590420425

✦ Synopsis

Abstract

Isooctane and other hydrocarbons inhibit the succinic‐cytochrome c reductase of a mitochondria preparation. This inhibition is not only due to the lipid solubility of these substances, but is caused, moreover, by other structural properties. A distinct dependence on the length of the side‐chain has been observed. Side‐chains with 6 to 7 carbon atoms are the most active ones. Introduction of a hydroxyl group into the n‐alkanes decreases the inhibitory effect, whereas it is increased by bromine substitution.