Heme synthetase activity in normal human and rat erythroid cells and in sideroblastic anemia
โ Scribed by N.J. Verhoef; P.J. Noordeloos; B. Leijnse
- Book ID
- 115821994
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 585 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0009-8981
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๐ SIMILAR VOLUMES
To examine the role of 5-aminolevulinate synthase (ALAS) in the pathogenesis of sideroblastic anemias, levels of mRNAs for erythroid and housekeeping ALAS isozymes were examined, and total ALAS activity was assessed in bone marrow cells. In two patients with X-linked sideroblastic anemia the levels
Belgrade (b) rats have an autosomal recessive, microcytic, hypochromic anemia. Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux. This experiment of nature permits the present study to address whether the mutation also affects