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Heme oxygenase is a heat shock protein and PEST protein in rat astroglial cells

✍ Scribed by Dr. Barney E. Dwyer; Robert N. Nishimura; Jean De Vellis; Tadashi Yoshida

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
729 KB
Volume
5
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

Cultured rat forebrain astrocytes contained significant amounts of immunostainable heme oxygenase‐1 (HO‐1) isozyme, whereas HO‐1 was undetectable in spontaneously transformed rat astroglial cells (ATs). HO‐1 was inducible in both cell types by heat shock and by submicromolar amounts of H~2~O~2~. Inhibition of RNA synthesis with actinomycin D or protein synthesis with cycloheximide resulted in the rapid loss of immunostainable heme oxygenase in astrocytes. Analysis of the primary structure of heme oxygenase suggests that it is a PEST protein, i.e., targeted for rapid turnover. Β© 1992 Wiley‐Liss, Inc.

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