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Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats

✍ Scribed by Bernhard Angermayr; Marc Mejias; Jorge Gracia-Sancho; Juan Carlos Garcia-Pagan; Jaime Bosch; Mercedes Fernandez


Book ID
116650920
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
245 KB
Volume
44
Category
Article
ISSN
0168-8278

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Heme oxygenase (HO) catalyzes the conversion of heme into biliverdin, iron, and carbon monoxide (CO). Two isoforms of HO have been identified: the inducible HO-1 and the constitutive HO-2. CO, like nitric oxide, is an endogenous vasodilator that could contribute to modulation of systemic and local v