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Heme Oxygenase and Angiogenic Activity of Endothelial Cells: Stimulation by Carbon Monoxide and Inhibition by Tin Protoporphyrin-IX

✍ Scribed by Józkowicz, Alicja; Huk, Ihor; Nigisch, Anneliese; Weigel, Guenter; Dietrich, Wolf; Motterlini, Roberto; Dulak, Józef

Book ID
120469886
Publisher
Mary Ann Liebert
Year
2003
Tongue
English
Weight
541 KB
Volume
5
Category
Article
ISSN
1523-0864

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Inhibition of heme oxygenase-1 by zinc p
Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice
✍ Kaeko Hirai; Tomonori Sasahira; Hitoshi Ohmori; Kiyomu Fujii; Hiroki Kuniyasu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 340 KB

## Abstract Heme oxygenase (HO)‐1 is a key player reducing cytotoxicity and enhancing protumoral effects of nitric oxide (NO). We examined zinc protoporphyrin (ZnPP) IX, an HO‐1 inhibitor, to affect tumor growth of LL/2 mouse lung cancer cells. ZnPPIX reduced HO‐1 expression and HO activity in LL/2