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Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice

✍ Scribed by Ohta, Ryo; Tanaka, Nobuhiro; Nakanishi, Kazuyoshi; Kamei, Naosuke; Nakamae, Toshio; Izumi, Bunichiro; Fujioka, Yuki; Ochi, Mitsuo


Book ID
118788189
Publisher
Springer
Year
2012
Tongue
English
Weight
767 KB
Volume
21
Category
Article
ISSN
0940-6719

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## Abstract Bach 1 is a transcription factor that negatively regulates the transcription of heme oxygenase‐1 (HO‐1), a stress‐responding protein. In this study, we investigated the reaction to oxidative stress in the meniscus of Bach 1 deficient mice, and the suppression of meniscal degeneration by