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Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor

✍ Scribed by Maria José Alcaraz; Aïda Habib; Christophe Créminon; Ana Marı&#x0301;a Vicente; Marilyne Lebret; Sylviane Lévy-Toledano; Jacques Maclouf

Book ID: 117480782
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 301 KB
Volume: 1526
Category: Article
ISSN: 0304-4165
DOI: 10.1016/s0304-4165(01)00112-x

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Induction of heme oxygenase (HO)-1 during inflammation has been demonstrated in many cell types, but the contribution of inflammatory molecules nitric oxide (NO) and prostaglandin E(2) (PGE(2)) has remained unresolved. Here we show that NO donors including sodium nitroprusside (SNP) and spermine non