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Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L-Arginine

✍ Scribed by Raffaele Lanteri; Rosaria Acquaviva; Claudia Di Giacomo; Rosario Caltabiano; Giovanni Li Destri; Luca Vanella; Marco Santangelo; Salvatore Lanzafame; Antonio Di Cataldo

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
260 KB
Volume
26
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

Ischemia/reperfusion (I/R) injury is a multifactorial process that affects liver function after transplantation and resectional surgery. Alterations in hepatic microcirculation and decreased hepatic flow can cause local hypoxia and consequently liver damage, which is worsened by reperfusion. The aim of this study was to evaluate if treatment with L‐arginine improved hepatic function in rats with I/R injury. Animals were treated with L‐arginine, ischemized for 30 min, and reperfused for 3 h. Plasmatic levels of GOT, GPT, lipid hydroperoxides (LOOH), and total thiol groups (RSH) were evaluated. In addition, we analyzed hepatic LOOH and RSH levels, DNA fragmentation, heme oxygenase 1 (HO‐1) expression, and histological modifications. Our results demonstrate a significant improvement in hepatic function of I/R rats compared to the control group. Treatment with L‐arginine increased the expression of HO‐1. These data suggest that L‐arginine could be useful in preventing oxidative damage during hepatic surgery. © 2006 Wiley‐Liss, Inc. Microsurgery 26: 25–32, 2006.

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