Heme-induced cell adhesion in the pathogenesis of sickle-cell disease and inflammation
β Scribed by Frank A.D.T.G Wagener; Nader G Abraham; Yvette van Kooyk; Theo de Witte; Carl G Figdor
- Book ID
- 117340470
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 438 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0165-6147
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## Abstract Sickle cell disease (SCD) is a class of hemoglobinopathy in humans, which causes a disruption of the normal activities in different systems. Although this disease begins with the polymerization of red blood cells during its deoxygenating phase, it can erupt into a cascade of debilitatin
## Abstract Reduced activity of naturally occurring anticoagulants (NOAC) protein C and protein S may contribute to vasoβocclusion in sickle cell disease (SCD). We studied whether protein C and S are related to clinical vasoβocclusion, hematological markers of disease severity (hemoglobin levels, l