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Heme-binding properties of heme detoxification protein from Plasmodium falciparum

โœ Scribed by Nakatani, Keisuke; Ishikawa, Haruto; Aono, Shigetoshi; Mizutani, Yasuhisa


Book ID
122654166
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
758 KB
Volume
439
Category
Article
ISSN
0006-291X

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Malaria parasites infecting host red blood cells degrade hemoglobin by detoxifying heme into hemozoin. This conversion of heme to hemozoin is performed by a potent protein called heme detoxification protein (HDP), making HDP an attractive target for antimalarial drug development. We studied the gene