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Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis

✍ Scribed by Gupta, Mamta; Gupta, Shiv K; Balliet, Arthur G; Hollander, Mary Christine; Fornace, Albert J; Hoffman, Barbara; Liebermann, Dan A

Book ID: 110069890
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 382 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208847

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## Abstract Gadd45a (Gadd45), Gadd45b (MyD118), and Gadd45g (CR6) constitute a family of evolutionarily conserved, small, acidic, nuclear proteins, which have been implicated in terminal differentiation, growth suppression, and apoptosis. How Gadd45 proteins function in negative growth control is n