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Hematologic response in patients with aplastic anemia after long-term administration of recombinant human granulocyte colony—stimulating factor and erythropoietin

✍ Scribed by Shuji Yonekura; Hiroshi Kawada; Shigeki Watanabe; Akira Masumoto; Yoshiaki Ogawa; Ryuki Fukuda; Hirokazu Nishihira; Shusuke Matsuyama; Shunnichi Katoh; Hiroshi Mouri; Shigeki Motomura; Shigeru Shionoya; Tomomitsu Hotta

Book ID
117322065
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
577 KB
Volume
19
Category
Article
ISSN
0149-2918

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Combination Therapy With Recombinant Hum
Combination Therapy With Recombinant Human Granulocyte Colony-Stimulating Factor and Erythropoietin in Aplastic Anemia
✍ Dr. Masahiro Imamura; Masanobu Kobayashi; Sumiko Kobayashi; Kohki Yoshida; Chika 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB 👁 1 views

## Abstract Recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) and erythropoietin (rhEPO) were used to treat patients with aplastic anemia (AA). In terms of effects on erythrocyte recovery, the combined use of rhG‐CSF and rhEPO showed a favorable response in 6 of 14 (42.9%) patients

Effect of recombinant human granulocyte
Effect of recombinant human granulocyte macrophage-colony stimulating factor in long-term marrow cultures from patients with aplastic anemia
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The hematopoietic system in patients with aplastic anemia (AA) shows both quantitative and qualitative deficiencies, i.e., reduced numbers of hematopoietic progenitor cells (HPC) and impaired HPC proliferation in long-term marrow cultures (LTMC). Since recombinant human granulocyte macrophage-colony