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Helix-helix packing angle preferences for finite helix axes

✍ Scribed by Dirk Walther; Clayton Springer; Fred E. Cohen


Book ID
101229176
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
89 KB
Volume
33
Category
Article
ISSN
0887-3585

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✦ Synopsis


Recently, James Bowie addressed the question of how to normalize correctly the distribution of observed helix-helix packing angles in proteins (Bowie, Nature Struct. Biol. 4:915-917, 1997). A hitherto unrealized yet significant bias toward crossed packing angles was revealed. However, the derived random reference distribution of packing angles requires that helices have to be assumed as infinite in length. Here, we complement Bowie's analysis by consideration of the more realistic case where helices are of finite length. As a result, the statistical bias toward near perpendicular packings appears to be even stronger.


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