Helix-Hairpin Transitions of a Designed Peptide Studied by a Generalized-Ensemble Simulation
✍ Scribed by Itoh, Satoru G.; Tamura, Atsuo; Okamoto, Yuko
- Book ID
- 127390646
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 930 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1549-9618
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📜 SIMILAR VOLUMES
a] All amino acids are l-amino acids, except when specifically designated (dPro). O represents ornithine. Bold residues indicate the positions that make up the aromatic cleft. Underlined residues indicate the turn sequence. Italic residues indicate a change in the position of the Trp in the linker r
## Abstract Designed octapeptides Boc‐Leu‐Val‐Val‐Aib‐^D^Xxx‐Leu‐Val‐Val‐OMe (^D^Xxx = ^D^Ala, 3a;^D^Val, 3c and ^D^Pro, 5a) and Boc‐Leu‐Phe‐Val‐Aib‐^D^Ala‐Leu‐Phe‐Val‐OMe (3b) have been investigated to construct models of a stable type I′ β‐turn nucleated hairpin and to generate systems for invest