Helix Formation in Unsolvated Peptides: Side Chain Entropy Is Not the Determining Factor

The critical main-chain length for helix

The critical main-chain length for helix formation in water: Determined in a peptide series with alternating Aib and Ala residues exclusively and detected with ECD spectroscopy

✍ Edoardo Longo; Alessandro Moretto; Fernando Formaggio; Claudio Toniolo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

## Abstract Critical main‐chain length for peptide helix formation in the crystal (solid) state and in organic solvents has been already reported. In this short communication, we describe our results aiming at assessing the aforementioned parameter in __water__ solution. To this goal, we synthesize